Renal hyperfiltration as a risk factor for chronic kidney disease: A health checkup cohort study.

ABSTRACT:

Introduction

Renal hyperfiltration (RHF) has been found to be an independent predictor of adverse cardiovascular outcome. However, it remains uncertain whether it is precursor of chronic kidney disease (CKD) in a healthy population.

Materials and methods

To determine relative risks and identify the predictor of incident proteinuria and decline of estimated glomerular filtration rate (eGFR) in subjects with RHF. A total of 55,992 subjects aged ≥20 years who underwent health check-up during 2004-2017 were included. Among them, 16,946 subjects who completed at least two health checkups were analyzed.

Results

A total of 949 (5.6%) subjects developed proteinuria and 98 (0.6%) subjects showed ≥ 30% of eGFR decline. The risk of incident proteinuria was significantly higher i

SUBMITTER: Oh SW 

PROVIDER: S-EPMC7470278 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature