Cell wall inhibitors increase the accumulation of rifampicin in Mycobacterium tuberculosis.
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ABSTRACT:
SUBMITTER: McNeil MB
PROVIDER: S-EPMC7470358 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Publications
Cell wall inhibitors increase the accumulation of rifampicin in <i>Mycobacterium tuberculosis</i>.
McNeil Matthew B MB Chettiar Somsundaram S Awasthi Divya D Parish Tanya T
Access microbiology 20190320 1
There is a need for new combination regimens for tuberculosis. Identifying synergistic drug combinations can avoid toxic side effects and reduce treatment times. Using a fluorescent rifampicin conjugate, we demonstrated that synergy between cell wall inhibitors and rifampicin was associated with increased accumulation of rifampicin. Increased accumulation was also associated with increased cellular permeability. ...[more]
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