Ontology highlight
ABSTRACT:
SUBMITTER: Prehn JHM
PROVIDER: S-EPMC7470775 | biostudies-literature | 2020 Apr
REPOSITORIES: biostudies-literature
Prehn Jochen H M JHM Jirström Elisabeth E
Acta pharmacologica Sinica 20200306 4
In this review, we summarise the evidence for a role of the ribonuclease angiogenin in the pathophysiology of neurodegenerative disorders, with a specific focus on Parkinson's disease (PD). Angiogenin is a stress-induced, secreted ribonuclease with both nuclear and cytosolic activities. Loss-of-function mutations in the angiogenin gene (ANG) have been initially discovered in familial cases of amyotrophic lateral sclerosis (ALS), however, variants in ANG have subsequently been identified in PD an ...[more]