Early childhood and adolescent risk factors for psychotic depression in a general population birth cohort sample.

ABSTRACT: BACKGROUND AND PURPOSE:In the group of severe mental disorders, psychotic depression (PD) is essentially under-researched. Knowledge about the risk factors is scarce and this applies especially to early risk factors. Our aim was to study early childhood and adolescent risk factors of PD in a representative birth cohort sample with a follow-up of up to 50 years. METHODS:The study was carried out using the Northern Finland Birth Cohort 1966 (NFBC 1966). We used non-psychotic depression (NPD) (n?=?746), schizophrenia (SZ) (n?=?195), psychotic bipolar disorder (PBD) (n?=?27), other psychoses (PNOS) (n?=?136) and healthy controls (HC) (n?=?8200) as comparison groups for PD (n?=?58). We analysed several potential early risk factors from time of birth until the age of 16 years. RESULTS:The main finding was that parents' psychiatric illness [HR 3.59 (1.84-7.04)] was a risk factor and a high sports grade in school was a protective factor [HR 0.29 (0.11-0.73)] for PD also after adjusting for covariates in the multivariate Cox regression model. Parental psychotic illness was an especially strong risk factor for PD. The PD subjects had a parent with psychiatric illness significantly more often (p?

SUBMITTER: Nietola M 

PROVIDER: S-EPMC7471190 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature