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Early childhood and adolescent risk factors for psychotic depression in a general population birth cohort sample.

ABSTRACT: BACKGROUND AND PURPOSE:In the group of severe mental disorders, psychotic depression (PD) is essentially under-researched. Knowledge about the risk factors is scarce and this applies especially to early risk factors. Our aim was to study early childhood and adolescent risk factors of PD in a representative birth cohort sample with a follow-up of up to 50 years. METHODS:The study was carried out using the Northern Finland Birth Cohort 1966 (NFBC 1966). We used non-psychotic depression (NPD) (n?=?746), schizophrenia (SZ) (n?=?195), psychotic bipolar disorder (PBD) (n?=?27), other psychoses (PNOS) (n?=?136) and healthy controls (HC) (n?=?8200) as comparison groups for PD (n?=?58). We analysed several potential early risk factors from time of birth until the age of 16 years. RESULTS:The main finding was that parents' psychiatric illness [HR 3.59 (1.84-7.04)] was a risk factor and a high sports grade in school was a protective factor [HR 0.29 (0.11-0.73)] for PD also after adjusting for covariates in the multivariate Cox regression model. Parental psychotic illness was an especially strong risk factor for PD. The PD subjects had a parent with psychiatric illness significantly more often (p?

SUBMITTER: Nietola M

PROVIDER: S-EPMC7471190 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

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Early childhood and adolescent risk factors for psychotic depression in a general population birth cohort sample.

Nietola Miika M Huovinen Hanna H Heiskala Anni A Nordström Tanja T Miettunen Jouko J Korkeila Jyrki J Jääskeläinen Erika E

Social psychiatry and psychiatric epidemiology 20200213 9

<h4>Background and purpose</h4>In the group of severe mental disorders, psychotic depression (PD) is essentially under-researched. Knowledge about the risk factors is scarce and this applies especially to early risk factors. Our aim was to study early childhood and adolescent risk factors of PD in a representative birth cohort sample with a follow-up of up to 50 years.<h4>Methods</h4>The study was carried out using the Northern Finland Birth Cohort 1966 (NFBC 1966). We used non-psychotic depress ...[more]

PMID: 32055894

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Project description:BackgroundIdentifying modifiable risk factors for child victimisation and polyvictimisation (exposure to multiple types of victimisation) is critical for informing prevention efforts, yet little evidence is available in low- and middle-income countries. The authors aimed to estimate the prevalence of child victimisation and polyvictimisation, and examine unique and shared risk factors in a population-based cohort in Southern Brazil.MethodsLifetime child victimisation was based on maternal report when children were aged 4 years old (N∼3900) and included five types of victimisation (conventional crime, child maltreatment, peer/sibling victimisation, sexual victimisation, and witnessing/indirect victimisation) and polyvictimisation. Based on a socioecological model, possible risk factors were examined in four levels: community, maternal and family, parent, and child.FindingsConventional crime and peer/sibling victimisation were the most common types of victimisation (46.0 and 46.5%, respectively), followed by witnessing/indirect victimisation (27.0%), and child maltreatment (11.3%). Sexual victimisation had the lowest prevalence (1.4%). One in 10 (10.1%) children experienced polyvictimisation. In general, boys had higher victimisation rates than girls. There were few risk factors related only to specific types of victimisation (e.g., child disability was uniquely associated with child maltreatment and peer/sibling victimisation). Instead, most risk factors were shared across nearly all victimisation types and also associated with polyvictimisation. These shared risk factors were: violent neighbourhood and low social cohesion, maternal adverse childhood experiences, younger maternal age, parental antisocial behaviour, intimate partner violence against mothers, and maternal depression.InterpretationThese findings reveal a general pattern of accumulative risk effects for different types of victimisation and polyvictimisation, rather than unique risk profiles in children aged four year Prevention efforts should target risk factors at multiple levels (e.g.,: community, maternal and family and parent) during early childhood.FundingWellcome Trust grant 10735_Z_18_Z.

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Early childhood and adolescent risk factors for psychotic depression in a general population birth cohort sample.

Publications

Early childhood and adolescent risk factors for psychotic depression in a general population birth cohort sample.

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