Ontology highlight
ABSTRACT:
SUBMITTER: Lee W
PROVIDER: S-EPMC7471497 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Lee Wonhwa W Ahn June Hong JH Park Hee Ho HH Kim Hong Nam HN Kim Hyelim H Yoo Youngbum Y Shin Hyosoo H Hong Kyung Soo KS Jang Jong Geol JG Park Chun Gwon CG Choi Eun Young EY Bae Jong-Sup JS Seo Young-Kyo YK
Signal transduction and targeted therapy 20200903 1
Sterol regulatory element binding protein-2 (SREBP-2) is activated by cytokines or pathogen, such as virus or bacteria, but its association with diminished cholesterol levels in COVID-19 patients is unknown. Here, we evaluated SREBP-2 activation in peripheral blood mononuclear cells of COVID-19 patients and verified the function of SREBP-2 in COVID-19. Intriguingly, we report the first observation of SREBP-2 C-terminal fragment in COVID-19 patients' blood and propose SREBP-2 C-terminal fragment ...[more]