Ontology highlight
ABSTRACT:
SUBMITTER: Sperry J
PROVIDER: S-EPMC7471621 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
iScience 20200813 9
Glioblastoma (GBM) metabolism has traditionally been characterized by a primary dependence on aerobic glycolysis, prompting the use of the ketogenic diet (KD) as a potential therapy. In this study we evaluated the effectiveness of the KD in GBM and assessed the role of fatty acid oxidation (FAO) in promoting GBM propagation. <i>In vitro</i> assays revealed FA utilization throughout the GBM metabolome and growth inhibition in nearly every cell line in a broad spectrum of patient-derived glioma ce ...[more]