Ontology highlight
ABSTRACT:
SUBMITTER: Yeh MT
PROVIDER: S-EPMC7472100 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Viruses 20200808 8
Enterovirus (EV)-D68 has been associated with epidemics in the United Sates in 2014, 2016 and 2018. This study aims to identify potential viral virulence determinants. We found that neonatal type I interferon receptor knockout mice are susceptible to EV-D68 infection via intraperitoneal inoculation and were able to recapitulate the paralysis process observed in human disease. Among the EV-D68 strains tested, strain US/MO-14-18949 caused no observable disease in this mouse model, whereas the othe ...[more]