Ontology highlight
ABSTRACT:
SUBMITTER: Ke X
PROVIDER: S-EPMC7472116 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Ke Xianliang X Zhang Yuan Y Liu Yan Y Miao Yuanjiu Y Zheng Caishang C Luo Dan D Sun Jianhong J Hu Qinxue Q Xu Yi Y Wang Hanzhong H Zheng Zhenhua Z
Viruses 20200813 8
Enterovirus 71 (EV71) is the major causative pathogen of human hand, foot, and mouth disease (hHFMD) and has evolved to use various cellular receptors for infection. However, the relationship between receptor preference and EV71 virulence has not been fully revealed. By using reverse genetics, we identified that a single E98K mutation in VP1 is responsible for rapid viral replication in vitro. The E98K mutation enhanced binding of EV71-GZCII to cells in a heparan sulfate (HS)-dependent manner, a ...[more]