Ontology highlight
ABSTRACT:
SUBMITTER: Helmova R
PROVIDER: S-EPMC7472235 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Viruses 20200818 8
A highly virulent strain (Hypr) of tick-borne encephalitis virus (TBEV) was serially subcultured in the mammalian porcine kidney stable (PS) and <i>Ixodes ricinus</i> tick (IRE/CTVM19) cell lines, producing three viral variants. These variants exhibited distinct plaque sizes and virulence in a mouse model. Comparing the full-genome sequences of all variants, several nucleotide changes were identified in different genomic regions. Furthermore, different sequential variants were revealed to co-exi ...[more]