Ontology highlight
ABSTRACT:
SUBMITTER: Wu C
PROVIDER: S-EPMC7472961 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Wu Chenyun C Du Xinyue X Tang Lili L Wu Jianhua J Zhao Wei W Guo Xiaokui X Liu Dengyu D Hu Wei W Helmby Helena H Chen Guangjie G Wang Zhaojun Z
Frontiers in immunology 20200821
Schistosome infection contributes to cancer development, but the mechanisms are still not well-understood. SjE16.7 is an EF-hand calcium-binding protein secreted from <i>Schistosoma japonicum</i> eggs. It is a neutrophil attractant and macrophage activator and, as such, plays an important role in the inflammatory granuloma response in schistosomiasis. Here, we show that SjE16.7 binds to host cells by interacting with receptors for advanced glycation end products (RAGE). This ligation leads to ac ...[more]