Time-dependent cytokine and chemokine changes in mouse cerebral cortex following a mild traumatic brain injury.
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ABSTRACT:
SUBMITTER: Tweedie D
PROVIDER: S-EPMC7473773 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Publications
Time-dependent cytokine and chemokine changes in mouse cerebral cortex following a mild traumatic brain injury.
Tweedie David D Karnati Hanuma Kumar HK Mullins Roger R Pick Chaim G CG Hoffer Barry J BJ Goetzl Edward J EJ Kapogiannis Dimitrios D Greig Nigel H NH
eLife 20200817
Traumatic brain injury (TBI) is a serious global health problem, many individuals live with TBI-related neurological dysfunction. A lack of biomarkers of TBI has impeded medication development. To identify new potential biomarkers, we time-dependently evaluated mouse brain tissue and neuronally derived plasma extracellular vesicle proteins in a mild model of TBI with parallels to concussive head injury. Mice (CD-1, 30-40 g) received a sham procedure or 30 g weight-drop and were euthanized 8, 24, ...[more]
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