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ABSTRACT: Background
Cognitive behavioral therapy (CBT), which includes exposure and response prevention (ERP), is effective in improving symptoms of obsessive-compulsive disorder (OCD). However, whether poor cognitive functions and autism spectrum disorder (ASD) traits affect the therapeutic response of patients with OCD to ERP-based CBT remains unclear. This study aimed to identify factors predictive of the therapeutic response of Japanese patients with OCD to ERP-based CBT.Methods
Forty-two Japanese outpatients with OCD were assessed using the Wechsler Adult Intelligence Scale-III (WAIS-III), Yale-Brown Obsessive-Compulsive Scale, Patient Health Questionnaire 9-item scale, and Autism Spectrum Quotient (AQ) at pre- and post-treatment. We used multiple regression analyses to estimate the effect on therapeutic response change. The treatment response change was set as a dependent variable in multiple regression analyses.Results
Multiple regression analyses showed that among independent variables, communication as an AQ sub-scale and Letter Number Sequencing as a WAIS-III sub-test predict the therapeutic response to ERP-based CBT .Conclusions
Our results suggest that diminished working memory (Letter Number Sequencing), poor communication skill (AQ sub-scale) may undermine responsiveness to ERP-based CBT among patients with OCD.Trial registration
UMIN, UMIN00024087 . Registered 20 September 2016 - Retrospectively registered (including retrospective data).
SUBMITTER: Hamatani S
PROVIDER: S-EPMC7473813 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Hamatani Sayo S Tsuchiyagaito Aki A Nihei Masato M Hayashi Yuta Y Yoshida Tokiko T Takahashi Jumpei J Okawa Sho S Arai Honami H Nagaoka Maki M Matsumoto Kazuki K Shimizu Eiji E Hirano Yoshiyuki Y
BMC psychiatry 20200904 1
<h4>Background</h4>Cognitive behavioral therapy (CBT), which includes exposure and response prevention (ERP), is effective in improving symptoms of obsessive-compulsive disorder (OCD). However, whether poor cognitive functions and autism spectrum disorder (ASD) traits affect the therapeutic response of patients with OCD to ERP-based CBT remains unclear. This study aimed to identify factors predictive of the therapeutic response of Japanese patients with OCD to ERP-based CBT.<h4>Methods</h4>Forty ...[more]