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A multimodal magnetoencephalography 7?T fMRI and 7?T proton MR spectroscopy study in first episode psychosis.


ABSTRACT: We combined magnetoencephalography (MEG), 7?T proton magnetic resonance spectroscopy (MRS), and 7?T fMRI during performance of a task in a group of 23 first episode psychosis (FEP) patients and 26 matched healthy controls (HC). We recorded both the auditory evoked response to 40?Hz tone clicks and the resting state in MEG. Neurometabolite levels were obtained from the anterior cingulate cortex (ACC). The fMRI BOLD response was obtained during the Stroop inhibitory control task. FEP showed a significant increase in resting state low frequency theta activity (p?

SUBMITTER: Gawne TJ 

PROVIDER: S-EPMC7473853 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

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A multimodal magnetoencephalography 7 T fMRI and 7 T proton MR spectroscopy study in first episode psychosis.

Gawne Timothy J TJ   Overbeek Gregory J GJ   Killen Jeffery F JF   Reid Meredith A MA   Kraguljac Nina V NV   Kraguljac Nina V NV   Denney Thomas S TS   Ellis Charles A CA   Lahti Adrienne C AC  

NPJ schizophrenia 20200904 1


We combined magnetoencephalography (MEG), 7 T proton magnetic resonance spectroscopy (MRS), and 7 T fMRI during performance of a task in a group of 23 first episode psychosis (FEP) patients and 26 matched healthy controls (HC). We recorded both the auditory evoked response to 40 Hz tone clicks and the resting state in MEG. Neurometabolite levels were obtained from the anterior cingulate cortex (ACC). The fMRI BOLD response was obtained during the Stroop inhibitory control task. FEP showed a sign  ...[more]

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2021-04-07 | GSE152026 | GEO