Ontology highlight
ABSTRACT:
SUBMITTER: Luczak ED
PROVIDER: S-EPMC7473864 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Luczak Elizabeth D ED Wu Yuejin Y Granger Jonathan M JM Joiner Mei-Ling A MA Wilson Nicholas R NR Gupta Ashish A Umapathi Priya P Murphy Kevin R KR Reyes Gaido Oscar E OE Sabet Amin A Corradini Eleonora E Tseng Wen-Wei WW Wang Yibin Y Heck Albert J R AJR Wei An-Chi AC Weiss Robert G RG Anderson Mark E ME
Nature communications 20200904 1
Despite the clear association between myocardial injury, heart failure and depressed myocardial energetics, little is known about upstream signals responsible for remodeling myocardial metabolism after pathological stress. Here, we report increased mitochondrial calmodulin kinase II (CaMKII) activation and left ventricular dilation in mice one week after myocardial infarction (MI) surgery. By contrast, mice with genetic mitochondrial CaMKII inhibition are protected from left ventricular dilation ...[more]