Ontology highlight
ABSTRACT:
SUBMITTER: Meng Y
PROVIDER: S-EPMC7474466 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Meng Yunxiao Y Chen Chi-Wei CW Yung Mingo M H MMH Sun Wei W Sun Jing J Li Zhuqing Z Li Jing J Li Zongzhu Z Zhou Wei W Liu Stephanie S SS Cheung Annie N Y ANY Ngan Hextan Y S HYS Braisted John C JC Kai Yan Y Peng Weiqun W Tzatsos Alexandros A Li Yiliang Y Dai Zhijun Z Zheng Wei W Chan David W DW Zhu Wenge W
Cancer letters 20180426
The acquisition of resistance is a major obstacle to the clinical use of platinum drugs for ovarian cancer treatment. Increase of DNA damage response is one of major mechanisms contributing to platinum-resistance. However, how DNA damage response is regulated in platinum-resistant ovarian cancer cells remains unclear. Using quantitative high throughput combinational screen (qHTCS) and RNA-sequencing (RNA-seq), we show that dual oxidase maturation factor 1 (DUOXA1) is overexpressed in platinum-re ...[more]