Ontology highlight
ABSTRACT:
SUBMITTER: Gerdes LA
PROVIDER: S-EPMC7474627 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Gerdes Lisa Ann LA Janoschka Claudia C Eveslage Maria M Mannig Bianca B Wirth Timo T Schulte-Mecklenbeck Andreas A Lauks Sarah S Glau Laura L Gross Catharina C CC Tolosa Eva E Flierl-Hecht Andrea A Ertl-Wagner Birgit B Barkhof Frederik F Meuth Sven G SG Kümpfel Tania T Wiendl Heinz H Hohlfeld Reinhard R Klotz Luisa L
Proceedings of the National Academy of Sciences of the United States of America 20200817 35
The tremendous heterogeneity of the human population presents a major obstacle in understanding how autoimmune diseases like multiple sclerosis (MS) contribute to variations in human peripheral immune signatures. To minimize heterogeneity, we made use of a unique cohort of 43 monozygotic twin pairs clinically discordant for MS and searched for disease-related peripheral immune signatures in a systems biology approach covering a broad range of adaptive and innate immune populations on the protein ...[more]