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Compression stiffening of fibrous networks with stiff inclusions.

ABSTRACT: Tissues commonly consist of cells embedded within a fibrous biopolymer network. Whereas cell-free reconstituted biopolymer networks typically soften under applied uniaxial compression, various tissues, including liver, brain, and fat, have been observed to instead stiffen when compressed. The mechanism for this compression-stiffening effect is not yet clear. Here, we demonstrate that when a material composed of stiff inclusions embedded in a fibrous network is compressed, heterogeneous rearrangement of the inclusions can induce tension within the interstitial network, leading to a macroscopic crossover from an initial bending-dominated softening regime to a stretching-dominated stiffening regime, which occurs before and independently of jamming of the inclusions. Using a coarse-grained particle-network model, we first establish a phase diagram for compression-driven, stretching-dominated stress propagation and jamming in uniaxially compressed two- and three-dimensional systems. Then, we demonstrate that a more detailed computational model of stiff inclusions in a subisostatic semiflexible fiber network exhibits quantitative agreement with the predictions of our coarse-grained model as well as qualitative agreement with experiments.

SUBMITTER: Shivers JL

PROVIDER: S-EPMC7474641 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

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Compression stiffening of fibrous networks with stiff inclusions.

Shivers Jordan L JL Feng Jingchen J van Oosten Anne S G ASG Levine Herbert H Janmey Paul A PA MacKintosh Fred C FC

Proceedings of the National Academy of Sciences of the United States of America 20200817 35

Tissues commonly consist of cells embedded within a fibrous biopolymer network. Whereas cell-free reconstituted biopolymer networks typically soften under applied uniaxial compression, various tissues, including liver, brain, and fat, have been observed to instead stiffen when compressed. The mechanism for this compression-stiffening effect is not yet clear. Here, we demonstrate that when a material composed of stiff inclusions embedded in a fibrous network is compressed, heterogeneous rearrange ...[more]

PMID: 32817547

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Dataset Information

Compression stiffening of fibrous networks with stiff inclusions.

Publications

Compression stiffening of fibrous networks with stiff inclusions.

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