Ontology highlight
ABSTRACT:
SUBMITTER: Okashah N
PROVIDER: S-EPMC7474645 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Okashah Najeah N Wright Shane C SC Kawakami Kouki K Mathiasen Signe S Zhou Joris J Lu Sumin S Javitch Jonathan A JA Inoue Asuka A Bouvier Michel M Lambert Nevin A NA
Proceedings of the National Academy of Sciences of the United States of America 20200817 35
G proteins are activated when they associate with G protein-coupled receptors (GPCRs), often in response to agonist-mediated receptor activation. It is generally thought that agonist-induced receptor-G protein association necessarily promotes G protein activation and, conversely, that activated GPCRs do not interact with G proteins that they do not activate. Here we show that GPCRs can form agonist-dependent complexes with G proteins that they do not activate. Using cell-based bioluminescence re ...[more]