Ontology highlight
ABSTRACT:
SUBMITTER: Itatani Y
PROVIDER: S-EPMC7474657 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Itatani Yoshiro Y Yamamoto Takamasa T Zhong Cuiling C Molinolo Alfredo A AA Ruppel Jane J Hegde Priti P Taketo M Mark MM Ferrara Napoleone N
Proceedings of the National Academy of Sciences of the United States of America 20200819 35
We tested <i>cis-Apc</i><sup><i>Δ716</i></sup><i>/Smad4</i><sup><i>+/-</i></sup> and <i>cis-Apc</i><sup><i>Δ716</i></sup><i>/Smad4</i><sup><i>+/-</i></sup><i>Kras</i><sup><i>G12D</i></sup> mice, which recapitulate key genetic abnormalities accumulating during colorectal cancer (CRC) tumorigenesis in humans, for responsiveness to anti-VEGF therapy. We found that even tumors in <i>cis-Apc</i><sup><i>Δ716</i></sup><i>/Smad4</i><sup><i>+/-</i></sup><i>Kras</i><sup><i>G12D</i></sup> mice, although hi ...[more]