Ontology highlight
ABSTRACT:
SUBMITTER: Nadella V
PROVIDER: S-EPMC7475467 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Annals of translational medicine 20200801 16
Macrophages are a major component of the tumor microenvironment (TME) of most tumors. They are characterized by a high degree of functional plasticity which enable these cells to both promote and eliminate established tumors. Under the influence of immunosuppressive TME, tumor infiltrating iNOS+ and CD11b+ M-1 effector macrophages get polarized towards tumor associated macrophages (TAM) which are tropic to variety of tumors. Increased infiltration and density of TAM is associated with tumor prog ...[more]