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Stable high frequency background EEG activity distinguishes epileptic from healthy brain regions.


ABSTRACT: High-frequency oscillations are markers of epileptic tissue. Recently, different patterns of EEG background activity were described from which high-frequency oscillations occur: high-frequency oscillations with continuously oscillating background were found to be primarily physiological, those from quiet background were linked to epileptic tissue. It is unclear, whether these interactions remain stable over several days and during different sleep-wake stages. High-frequency oscillation patterns (oscillatory vs. quiet background) were analysed in 23 patients implanted with depth and subdural grid electrodes. Pattern scoring was performed on every channel in 10?s intervals in three separate day- and night-time EEG segments. An entropy value, measuring variability of patterns per channel, was calculated. A low entropy value indicated a stable occurrence of the same pattern in one channel, whereas a high value indicated pattern instability. Differences in pattern distribution and entropy were analysed for 143?280 10?s intervals with allocated patterns from inside and outside the seizure onset zone, different electrode types and brain regions. We found a strong association between high-frequency oscillations out of quiet background activity, and channels of the seizure onset zone (35.2% inside versus 9.7% outside the seizure onset zone, P?

SUBMITTER: Minthe A 

PROVIDER: S-EPMC7475693 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Stable high frequency background EEG activity distinguishes epileptic from healthy brain regions.

Minthe Annika A   Janzarik Wibke G WG   Lachner-Piza Daniel D   Reinacher Peter P   Schulze-Bonhage Andreas A   Dümpelmann Matthias M   Jacobs Julia J  

Brain communications 20200722 2


High-frequency oscillations are markers of epileptic tissue. Recently, different patterns of EEG background activity were described from which high-frequency oscillations occur: high-frequency oscillations with continuously oscillating background were found to be primarily physiological, those from quiet background were linked to epileptic tissue. It is unclear, whether these interactions remain stable over several days and during different sleep-wake stages. High-frequency oscillation patterns  ...[more]

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