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Hydroxysafflor yellow A promotes multiterritory perforating flap survival: an experimental study.


ABSTRACT: The use of perforator flaps is a common surgical technique in wound repair. However, the area surrounding the multiterritory perforating flap often becomes necrotic due to ischemia. Hydroxysafflor yellow A (HSYA), a traditional Chinese medicine extracted from edible safflower, can be used medicinally to promote angiogenesis, inhibit apoptosis, and alleviate oxidative stress and other biological activities. Here, we investigated the effect of HSYA on perforator flap survival and its potential mechanism. Our results demonstrate that HSYA significantly improves the survival area of perforator flaps, increases blood supply, reduces tissue edema, and increases mean vascular density. HSYA treatment promotes angiogenesis and inhibits oxidative stress, apoptosis, and autophagy in perforator flaps, suggesting many potential mechanisms for flap survival.

SUBMITTER: Zhang C 

PROVIDER: S-EPMC7476167 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Hydroxysafflor yellow A promotes multiterritory perforating flap survival: an experimental study.

Zhang Chenxi C   Shao Zhenxuan Z   Chen Zhentai Z   Lin Chen C   Hu Sunli S   Lou Zhiling Z   Li Jiafeng J   Zheng Xuanqi X   Lin Nan N   Gao Weiyang W  

American journal of translational research 20200815 8


The use of perforator flaps is a common surgical technique in wound repair. However, the area surrounding the multiterritory perforating flap often becomes necrotic due to ischemia. Hydroxysafflor yellow A (HSYA), a traditional Chinese medicine extracted from edible safflower, can be used medicinally to promote angiogenesis, inhibit apoptosis, and alleviate oxidative stress and other biological activities. Here, we investigated the effect of HSYA on perforator flap survival and its potential mec  ...[more]

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