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Muyocopronones A and B: azaphilones from the endophytic fungus Muyocopron laterale.

ABSTRACT: Two new azaphilones, namely muyocopronones A (1) and B (2), were isolated from the cultures of an endophytic fungus Muyocopron laterale ECN279. Their structures were elucidated by extensive spectroscopic analysis. Their absolute configurations were determined using the modified Mosher's method and through comparisons of experimental and calculated electronic circular dichroism data. In addition, muyocopronone B (2) was found to exhibit a weak antibacterial activity against some Gram-positive bacteria.

SUBMITTER: Nakashima KI

PROVIDER: S-EPMC7476592 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Muyocopronones A and B: azaphilones from the endophytic fungus Muyocopron laterale.

Nakashima Ken-Ichi KI Tomida Junko J Tsuboi Tomoe T Kawamura Yoshiaki Y Inoue Makoto M

Beilstein journal of organic chemistry 20200828

Two new azaphilones, namely muyocopronones A (1) and B (2), were isolated from the cultures of an endophytic fungus Muyocopron laterale ECN279. Their structures were elucidated by extensive spectroscopic analysis. Their absolute configurations were determined using the modified Mosher's method and through comparisons of experimental and calculated electronic circular dichroism data. In addition, muyocopronone B (2) was found to exhibit a weak antibacterial activity ag ...[more]

PMID: 32952726

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