Association of Alopecia Areata with Vitamin D and Calcium Levels: A Systematic Review and Meta-analysis.

ABSTRACT: INTRODUCTION:To investigate the associations of alopecia areata (AA) with serum vitamin D and calcium levels. METHODS:A systematic review of all relevant articles published up to February 2020 in PubMed, Embase, and Cochrane Library databases was conducted. Primary endpoints were serum 25-hydroxyvitamin D [25(OH)D] levels and vitamin D deficiency, and the secondary endpoint was serum calcium level. Odds ratio (OR) and standardized mean difference (SMD) with 95% CI across studies were analyzed. RESULTS:Data on 1585 patients with AA and 1114 controls from 16 case-control studies and three cross-sectional studies were included in this meta-analysis. A pooled meta-analysis was conducted using the random-effects model because of inter-study heterogeneity (vitamin D level, I2?=?87.90%; vitamin D deficiency, I2?=?81.10%; serum calcium level, I2?=?83.80%). A combined analysis revealed that patients with AA had significantly lower mean serum 25(OH)D level compared with control (WMD -?9.08, 95% CI -?11.65, -?6.50, p?

SUBMITTER: Liu Y 

PROVIDER: S-EPMC7477029 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature