Intracellular ATP levels in mouse cortical excitatory neurons varies with sleep-wake states.
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ABSTRACT:
SUBMITTER: Natsubori A
PROVIDER: S-EPMC7477120 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Publications
Intracellular ATP levels in mouse cortical excitatory neurons varies with sleep-wake states.
Natsubori Akiyo A Tsunematsu Tomomi T Karashima Akihiro A Imamura Hiromi H Kabe Naoya N Trevisiol Andrea A Hirrlinger Johannes J Kodama Tohru T Sanagi Tomomi T Masamoto Kazuto K Takata Norio N Nave Klaus-Armin KA Matsui Ko K Tanaka Kenji F KF Honda Makoto M
Communications biology 20200907 1
Whilst the brain is assumed to exert homeostatic functions to keep the cellular energy status constant under physiological conditions, this has not been experimentally proven. Here, we conducted in vivo optical recordings of intracellular concentration of adenosine 5'-triphosphate (ATP), the major cellular energy metabolite, using a genetically encoded sensor in the mouse brain. We demonstrate that intracellular ATP levels in cortical excitatory neurons fluctuate in a cortex-wide manner dependin ...[more]
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