Ontology highlight
ABSTRACT:
SUBMITTER: Guerrero Llobet S
PROVIDER: S-EPMC7477160 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Guerrero Llobet Sergi S van der Vegt Bert B Jongeneel Evelien E Bense Rico D RD Zwager Mieke C MC Schröder Carolien P CP Everts Marieke M Fehrmann Rudolf S N RSN de Bock Geertruida H GH van Vugt Marcel A T M MATM
NPJ breast cancer 20200907
Replication stress entails the improper progression of DNA replication. In cancer cells, including breast cancer cells, an important cause of replication stress is oncogene activation. Importantly, tumors with high levels of replication stress may have different clinical behavior, and high levels of replication stress appear to be a vulnerability of cancer cells, which may be therapeutically targeted by novel molecularly targeted agents. Unfortunately, data on replication stress is largely based ...[more]