Ontology highlight
ABSTRACT:
SUBMITTER: Fujiyoshi K
PROVIDER: S-EPMC7477375 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Fujiyoshi Kenji K Chen Yang Y Chen Yang Y Haruki Koichiro K Ugai Tomotaka T Kishikawa Junko J Hamada Tsuyoshi T Liu Li L Arima Kota K Borowsky Jennifer J Väyrynen Juha P JP Zhao Melissa M Lau Mai Chan MC Gu Simeng S Shi Shanshan S Akimoto Naohiko N Twombly Tyler S TS Drew David A DA Song Mingyang M Chan Andrew T AT Giovannucci Edward L EL Meyerhardt Jeffrey A JA Fuchs Charles S CS Nishihara Reiko R Lennerz Jochen K JK Giannakis Marios M Nowak Jonathan A JA Zhang Xuehong X Wu Kana K Ogino Shuji S
JNCI cancer spectrum 20200514 5
<h4>Background</h4>Smoking has been associated with worse colorectal cancer patient survival and may potentially suppress the immune response in the tumor microenvironment. We hypothesized that the prognostic association of smoking behavior at colorectal cancer diagnosis might differ by lymphocytic reaction patterns in cancer tissue.<h4>Methods</h4>Using 1474 colon and rectal cancer patients within 2 large prospective cohort studies (Nurses' Health Study and Health Professionals Follow-up Study) ...[more]