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Pancreatic fat accumulation evaluated by multidetector computed tomography in patients with type 2 diabetes.

ABSTRACT: AIMS:To clarify the clinical impact of pancreatic fat volume on beta cell function in type 2 diabetes patients. MATERIALS AND METHODS:One hundred thirty two consecutive type 2 diabetic patients (mean age, 63.7 years) were enrolled in this cross-sectional study. Total pancreatic volume (TPV), pancreatic fat volume (PFV), and pancreatic parenchymal volume (PPV), and visceral fat volume were examined quantitatively with multidetector computed tomography using SYNAPSE VINCENT image analysis system (Fujifilm Inc., Tokyo, Japan). Pancreatic fat was identified using Hounsfield Units of less than zero. The capacity of insulin secretion was assessed by C-peptide immunoreactivity (CPR) index (100 × fasting CPR/fasting plasma glucose). Insulin sensitivity was evaluated using CPR-insulin resistance (20/fasting CPR × fasting plasma glucose). RESULTS:TPV, PFV, PPV, and visceral fat volume were significantly correlated with body weight (BW). PPV/BW, but not PFV/BW, significantly decreased with increasing duration of diabetes and aging. PFV/BW was positively associated with body mass index and visceral fat volume/BW. PFV/BW was significantly correlated with CPR index, while inversely associated with insulin sensitivity. CPR index, but not CPRinsulin resistance was progressively decreased in patients with a longer duration of diabetes. When patients were divided into two groups according to a median PFV/BW value, CPR index in high PFV/BW group with diabetes duration >5 years was significantly lower than those ?5 years. However, duration-dependent decrease in CPR index was not observed in low PFV/BW group. CONCLUSIONS:Our present study suggests that PFV might predict the progression of beta cell dysfunction in patients with type 2 diabetes.

SUBMITTER: Fukase A

PROVIDER: S-EPMC7477536 | biostudies-literature | 2020 Mar

REPOSITORIES: biostudies-literature

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Pancreatic fat accumulation evaluated by multidetector computed tomography in patients with type 2 diabetes.

Fukase Ayako A Fukui Tomoyasu T Sasamori Hiroto H Hiromura Munenori M Terasaki Michishige M Mori Yusaku Y Hayashi Toshiyuki T Yamamoto Takeshi T Ohara Makoto M Goto Satoshi S Nagaike Hiroe H Hirano Tsutomu T Yamagishi Sho-Ichi SI

Journal of diabetes investigation 20200414 5

<h4>Aims</h4>To clarify the clinical impact of pancreatic fat volume on beta cell function in type 2 diabetes patients.<h4>Materials and methods</h4>One hundred thirty two consecutive type 2 diabetic patients (mean age, 63.7 years) were enrolled in this cross-sectional study. Total pancreatic volume (TPV), pancreatic fat volume (PFV), and pancreatic parenchymal volume (PPV), and visceral fat volume were examined quantitatively with multidetector computed tomography using SYNAPSE VINCENT image an ...[more]

PMID: 32129002

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Project description:BackgroundDiffuse interstitial lung disease have been described in Neurofibromatosis type 1 (NF1), but its diversity and prevalence remain unknown. The aim of this study was to assess the prevalence and characteristics of (NF1)-associated lung manifestations in a large single-center study using multidetector computed tomography (MDCT) and to evaluate the smoking history, patients' age, genetics, and the presence of malignant peripheral nerve sheath tumors (MPNST) as potential influencing factors for lung pathologies.MethodsIn this retrospective study, 71 patients with NF1 were evaluated for the presence of distinctive lung manifestations like reticulations, consolidations, type of emphysema, pulmonary nodules and cysts. All patients underwent F-18-FDG PET/CT scans, which were reviewed by two experienced radiologists in consensus. Patients' subgroups were formed based on their smoking history (current smokers/previous smokers/never smokers), age (<?12 years, 12-18 years, >?18 years), and presence of MPNST (MPNST/no MPNST). In 57 patients (80%), genetic analysis of sequences coding for the neurofibromin on chromosome 17 was performed, which was correlated with different lung pathologies.ResultsAmong all NF1 patients (33?±?14 years, 56% females), 17 patients (24%) were current smokers and 62 patients (87%) were?>?18 years old. Pulmonary cysts, nodules, and paraseptal emphysema were the most common pulmonary findings (35%, 32%, 30%). The presence of pulmonary metastases, MPNST and centrilobular emphysema was associated with smoking. Cysts were observed only in adults, whereas no significant correlation between age and all other pulmonary findings was found (p?>?0.05). Presence of MPNST was accompanied by higher rates of intrapulmonary nodules and pulmonary metastasis. Neither the presence nor absence of any of the specific gene mutations was associated with any particular lung pathology (p?>?0.05).ConclusionsAll pulmonary findings in NF1 patients occurred independently from specific mutation subtypes, suggesting that many NF1 mutations can cause various pulmonary pathologies. The presence of pulmonary metastases, MPNST and centrilobular emphysema was associated with smoking, indicating the value of smoking secession or the advice not to start smoking in NF1 patients as preventive strategy for clinicians. For screening of pulmonary manifestations in NF1 patients, an MDCT besides medical history and physical examination is mandatory in clinical routine.

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Pancreatic fat accumulation evaluated by multidetector computed tomography in patients with type 2 diabetes.

Publications

Pancreatic fat accumulation evaluated by multidetector computed tomography in patients with type 2 diabetes.

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