Ontology highlight
ABSTRACT:
SUBMITTER: Abu-Shah E
PROVIDER: S-EPMC7477745 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Abu-Shah Enas E Trendel Nicola N Kruger Philipp P Nguyen John J Pettmann Johannes J Kutuzov Mikhail M Dushek Omer O
Journal of immunology (Baltimore, Md. : 1950) 20200817 6
T cells recognizing cognate pMHC Ags become activated to elicit a myriad of cellular responses, such as target cell killing and the secretion of different cytokines, that collectively contribute to adaptive immunity. These effector responses have been hypothesized to exhibit different Ag dose and affinity thresholds, suggesting that pathogen-specific information may be encoded within the nature of the Ag. In this study, using systematic experiments in a reductionist system, in which primary huma ...[more]