Ontology highlight
ABSTRACT:
SUBMITTER: Chen B
PROVIDER: S-EPMC7478007 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Chen Baoyu B Yuan Yibiao Y Sun Lina L Chen Junliang J Yang Mengzhu M Yin Yongmei Y Xu Yong Y
Frontiers in cell and developmental biology 20200825
Differential regulation of gene transcription contributes to cancer metastasis. We investigated the involvement of a Rho GTPase (RhoJ) in breast cancer metastasis focusing on the mechanism underlying RhoJ <i>trans</i>-activation by pro-metastatic cues. We report that expression of RhoJ was up-regulated in malignant breast cancer cells compared to more benign ones. Higher RhoJ expression was also detected in human breast cancer biopsy specimens of advanced stages. RhoJ depletion attenuated breast ...[more]