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Predicting Factors Associated with Hypoglycemia Reduction with Automated Predictive Insulin Suspension in Patients at High Risk of Severe Hypoglycemia: An Analysis from the SMILE Randomized Trial.


ABSTRACT: Background: This analysis from the SMILE randomized study was performed to identify predictive factors associated with the greatest reductions in hypoglycemia with the Medtronic MiniMed™ 640G Suspend before low feature in adults with type 1 diabetes at high risk of severe hypoglycemia. Methods: Clinical and treatment-related factors associated with decreased sensor hypoglycemia (SH) were identified in participants from the intervention arm by univariate and multivariate analyses. Results: The reduction in SH events <54?mg/dL (<3.0?mmol/L) in the intervention group was significantly (P?

SUBMITTER: Habteab A 

PROVIDER: S-EPMC7478192 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

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Predicting Factors Associated with Hypoglycemia Reduction with Automated Predictive Insulin Suspension in Patients at High Risk of Severe Hypoglycemia: An Analysis from the SMILE Randomized Trial.

Habteab Aklilu A   Castañeda Javier J   de Valk Harold H   Choudhary Pratik P   Bosi Emanuele E   Lablanche Sandrine S   de Portu Simona S   Da Silva Julien J   Vorrink-de Groot Linda L   Shin John J   Cohen Ohad O  

Diabetes technology & therapeutics 20200901 9


<b><i>Background:</i></b> This analysis from the SMILE randomized study was performed to identify predictive factors associated with the greatest reductions in hypoglycemia with the Medtronic MiniMed™ 640G Suspend before low feature in adults with type 1 diabetes at high risk of severe hypoglycemia. <b><i>Methods:</i></b> Clinical and treatment-related factors associated with decreased sensor hypoglycemia (SH) were identified in participants from the intervention arm by univariate and multivaria  ...[more]

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