Ontology highlight
ABSTRACT:
SUBMITTER: Recouvreux MV
PROVIDER: S-EPMC7478719 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
The Journal of experimental medicine 20200901 9
Tumor cells rely on glutamine to fulfill their metabolic demands and sustain proliferation. The elevated consumption of glutamine can lead to intratumoral nutrient depletion, causing metabolic stress that has the potential to impact tumor progression. Here, we show that nutrient stress caused by glutamine deprivation leads to the induction of epithelial-mesenchymal transition (EMT) in pancreatic ductal adenocarcinoma (PDAC) cells. Mechanistically, we demonstrate that glutamine deficiency regulat ...[more]