Ontology highlight
ABSTRACT:
SUBMITTER: Cieslak A
PROVIDER: S-EPMC7478722 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Cieslak Agata A Charbonnier Guillaume G Tesio Melania M Mathieu Eve-Lyne EL Belhocine Mohamed M Touzart Aurore A Smith Charlotte C Hypolite Guillaume G Andrieu Guillaume P GP Martens Joost H A JHA Janssen-Megens Eva E Gut Marta M Gut Ivo I Boissel Nicolas N Petit Arnaud A Puthier Denis D Macintyre Elizabeth E Stunnenberg Hendrik G HG Spicuglia Salvatore S Asnafi Vahid V
The Journal of experimental medicine 20200901 9
Cell differentiation is accompanied by epigenetic changes leading to precise lineage definition and cell identity. Here we present a comprehensive resource of epigenomic data of human T cell precursors along with an integrative analysis of other hematopoietic populations. Although T cell commitment is accompanied by large scale epigenetic changes, we observed that the majority of distal regulatory elements are constitutively unmethylated throughout T cell differentiation, irrespective of their a ...[more]