Ontology highlight
ABSTRACT:
SUBMITTER: Pallett LJ
PROVIDER: S-EPMC7478732 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
The Journal of experimental medicine 20200901 9
The human liver contains specialized subsets of mononuclear phagocytes (MNPs) and T cells, but whether these have definitive features of tissue residence (long-term retention, lack of egress) and/or can be replenished from the circulation remains unclear. Here we addressed these questions using HLA-mismatched liver allografts to discriminate the liver-resident (donor) from the infiltrating (recipient) immune composition. Allografts were rapidly infiltrated by recipient leukocytes, which recapitu ...[more]