Ontology highlight
ABSTRACT:
SUBMITTER: Wang WW
PROVIDER: S-EPMC7478814 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Wang Wei Wei WW Wang Yamei Y Li Kang K Tadagavadi Raghu R Friedrichs William E WE Budatha Madhusudhan M Reeves W Brian WB
PloS one 20200908 9
Interleukin-10 (IL-10), a cytokine with anti-inflammatory effects, is produced by renal parenchymal cells and bone marrow derived cells. Both endogenous and exogenous IL-10 are protective in cisplatin-induced acute kidney injury. However, the source of endogenous IL-10 in cisplatin-induced nephrotoxicity is not clear. Bone marrow chimera experiments in IL10-KO mice indicated that bone marrow derived cells were the primary source of IL-10 in cisplatin nephrotoxicity. Cell specific deletion of IL- ...[more]