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The effect of acute stress on salivary markers of inflammation: A systematic review and meta-analysis.

ABSTRACT:

Background

Salivary biomarkers of inflammation are increasingly used in stress research. This systematic review and meta-analysis provides a quantitative summary of changes in salivary inflammatory markers in response to acute stress.

Method

The review included 1558 participants (42 unique samples, 33 studies) obtained through electronic databases (PubMed, PsycINFO, Embase), reference treeing, and articles identified by a 2015 review on a similar topic. To be eligible, articles had to be quantitative and assess change in at least one biomarker of salivary inflammation in response to acute stress in adults. The primary outcome was magnitude of change in inflammatory biomarkers (Cohen's d for repeated measures [d_av]).

Results

Measures of salivary inflammation included: C-reactive protein (CRP), granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukin (IL)-1β, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12p70, IL-13, IL-17A, IL-18, IL-21, interferon (IFN)-α, IFN-γ, and tumor necrosis factor (TNF)-α. Cytokines IL-6 (k = 26, d_av = 0.27), IL-10 (k = 11, d_av = 0.34), TNF-α (k = 10, d_av = 0.57), and IFN-γ (k = 6, d_av = 0.28) significantly increased in response to stress. Post hoc sensitivity analyses revealed that IL-1β (k = 19, d_av = 0.16) and IL-8 (k = 7, d_av = 0.30) also increased from pre- to post-stress, but findings with IFN-γ did not hold after removing one outlier study. Examination of moderators suggested that study methodology and sample demographics moderated some associations.

Conclusions

This meta-analysis revealed that certain salivary inflammatory cytokines increase in response to acute stress. Significant heterogeneity in results and moderator analyses suggest need for standardization of research protocols. Directions for future research are discussed.

SUBMITTER: Szabo YZ

PROVIDER: S-EPMC7478864 | biostudies-literature |

REPOSITORIES: biostudies-literature

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Project description:BackgroundThere is an increasing interest in the ability to non-invasively assess biological markers of stress. Measures of inflammation following exposure to acute stress have been assessed in saliva, but a systematic review and meta-analysis of the reliability of changes in response to stress has not been conducted. The proposed review aims to update and extend a prior review of this literature by performing a systematic review and meta-analysis, conducting moderator analyses, summarizing and reviewing best practices, and providing recommendations for future research.Methods and analysisThe adopted search strategy will involve the electronic databases PubMed, PsycINFO, and Embase. We will include the articles identified by a 2015 narrative review on a similar topic, as well as use reference treeing to identify additional potentially relevant articles. Identified articles will be independently screened by title and abstract. The full text of potentially relevant articles will then be retrieved and read for full inclusion criteria. Data will be extracted, and random-effects meta-analyses will be conducted in R for articles determined to meet all inclusion criteria. The primary outcome will be the magnitude of changes in inflammatory biomarkers following acute stress exposure, as indicated by Cohen's d. Participant psychosocial or demographic (e.g., age, gender/sex, race/ethnicity, salivary flow rate, oral health status, health status) and methodological (e.g., stressor type, sample timing, assay technique, sample collection method, study quality) moderators of this response also will be examined using meta-regression.DiscussionThis systematic review will synthesize the evidence regarding salivary markers of inflammation in response to acute stress. We anticipate variation across studies but hypothesize that salivary markers of inflammation will increase in response to acute stress. The evidence obtained for this study will help guide future research by providing guidelines for the design and measurement of studies assessing salivary inflammation in response to acute stress. Findings will be disseminated with a peer-reviewed manuscript and an international conference presentation.

Project description:OBJECTIVES:To examine the effect of nut consumption on inflammatory biomarkers and endothelial function. DESIGN:A systematic review and meta-analysis. DATA SOURCES:MEDLINE, PubMed, Cumulative Index to Nursing and Allied Health Literature and Cochrane Central Register of Controlled Trials (all years to 13 January 2017). ELIGIBILITY CRITERIA:Randomised controlled trials (with a duration of 3?weeks or more) or prospective cohort designs conducted in adults; studies assessing the effect of consumption of tree nuts or peanuts on C-reactive protein (CRP), adiponectin, tumour necrosis factor alpha, interleukin-6, intercellular adhesion molecule 1, vascular cell adhesion protein 1 and flow-mediated dilation (FMD). DATA EXTRACTION AND ANALYSIS:Relevant data were extracted for summary tables and analyses by two independent researchers. Random effects meta-analyses were conducted to explore weighted mean differences (WMD) in change or final mean values for each outcome. RESULTS:A total of 32 studies (all randomised controlled trials) were included in the review. The effect of nut consumption on FMD was explored in nine?strata from eight studies (involving 652 participants), with consumption of nuts resulting in significant improvements in FMD (WMD: 0.79%(95% CI 0.35 to 1.23)). Nut consumption resulted in small, non-significant differences in CRP (WMD: -0.01?mg/L (95%?CI -0.06 to 0.03)) (26?strata from 25 studies), although sensitivity analyses suggest results for CRP may have been influenced by two individual studies. Small, non-significant differences were also found for other biomarkers of inflammation. CONCLUSIONS:This systematic review and meta-analysis of the effects of nut consumption on inflammation and endothelial function found evidence for favourable effects on FMD, a measure of endothelial function. Non-significant changes in other biomarkers indicate a lack of consistent evidence for effects of nut consumption on inflammation. The findings of this analysis suggest a need for more research in this area, with a particular focus on randomised controlled trials. PROSPERO REGISTRATION NUMBER:CRD42016045424.