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Human genetic determinants of the gut microbiome and their associations with health and disease: a phenome-wide association study.

ABSTRACT: Small-scale studies have suggested a link between the human gut microbiome and highly prevalent diseases. However, the extent to which the human gut microbiome can be considered a determinant of disease and healthy aging remains unknown. We aimed to determine the spectrum of diseases that are linked to the human gut microbiome through the utilization of its genetic determinants as a proxy for its composition. 180 single nucleotide polymorphisms (SNPs) known to influence the human gut microbiome were used to assess the association with health and disease outcomes in 422,417 UK Biobank participants. Potential causal estimates were obtained using a Mendelian randomization (MR) approach. From the total sample analysed (mean age was 57?±?8 years), 194,567 (46%) subjects were male. Median exposure was 66-person years (interquartile range 59-72). Eleven SNPs were significantly associated with 28 outcomes (Bonferroni corrected P value?

SUBMITTER: Groot HE 

PROVIDER: S-EPMC7479141 | biostudies-literature | 2020 Sep

REPOSITORIES: biostudies-literature

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Human genetic determinants of the gut microbiome and their associations with health and disease: a phenome-wide association study.

Groot Hilde E HE   van de Vegte Yordi J YJ   Verweij Niek N   Lipsic Erik E   Karper Jacco C JC   van der Harst Pim P  

Scientific reports 20200908 1

Small-scale studies have suggested a link between the human gut microbiome and highly prevalent diseases. However, the extent to which the human gut microbiome can be considered a determinant of disease and healthy aging remains unknown. We aimed to determine the spectrum of diseases that are linked to the human gut microbiome through the utilization of its genetic determinants as a proxy for its composition. 180 single nucleotide polymorphisms (SNPs) known to influence the human gut microbiome  ...[more]

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