Machado-Joseph Deubiquitinases: From Cellular Functions to Potential Therapy Targets.
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ABSTRACT:
SUBMITTER: Zeng C
PROVIDER: S-EPMC7479174 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
Machado-Joseph Deubiquitinases: From Cellular Functions to Potential Therapy Targets.
Zeng Chenming C Zhao Chenxi C Ge Fujing F Li Yuekang Y Cao Ji J Ying Meidan M Lu Jinjian J He Qiaojun Q Yang Bo B Dai Xiaoyang X Zhu Hong H
Frontiers in pharmacology 20200826
Ubiquitination is known as important post-translational modification in cancer-related pathways. Human deubiquitinases (DUBs), with functions of modulating the ubiquitination process, are a family with about 100 proteins. They mainly function by cutting ubiquitin chains of the substrates. The Machado-Joseph domain-containing proteases (MJDs) is one of the sub-families of DUBs, consisting of four members, namely, Ataxin-3, Ataxin-3L, JOSD1, and JOSD2. Recent studies have provided new insights int ...[more]
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