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Connections that characterize callousness: Affective features of psychopathy are associated with personalized patterns of resting-state network connectivity.

ABSTRACT: BACKGROUND:Psychopathic traits are hypothesized to be associated with dysfunction across three resting-state networks: the default mode (DMN), salience (SN), and central executive (CEN). Past work has not considered heterogeneity in the neural networks of individuals who display psychopathic traits, which is likely critical in understanding the etiology of psychopathy and could underlie different symptom presentations. Thus, this study maps person-specific resting state networks and links connectivity patterns to features of psychopathy. METHODS:We examined resting-state functional connectivity among eight regions of interest in the DMN, SN, and CEN using a person-specific, sparse network mapping approach (Group Iterative Multiple Model Estimation) in a community sample of 22-year-old men from low-income, urban families (N = 123). Associations were examined between a dimensional measure of psychopathic traits and network density (i.e., number of connections within and between networks). RESULTS:There was significant heterogeneity in neural networks of participants, which were characterized by person-specific connections and no common connections across the sample. Psychopathic traits, particularly affective traits, were associated with connection density between the DMN and CEN, such that greater density was associated with elevated psychopathic traits. DISCUSSION:Findings emphasize that neural networks underlying psychopathy are highly individualized. However, individuals with high levels of psychopathic traits had increased density in connections between the DMN and CEN, networks that have been linked with self-referential thinking and executive functioning. Taken together, the results highlight the utility of person-specific approaches in modeling neural networks underlying psychopathic traits, which could ultimately inform personalized prevention and intervention strategies.

SUBMITTER: Dotterer HL

PROVIDER: S-EPMC7479442 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

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Connections that characterize callousness: Affective features of psychopathy are associated with personalized patterns of resting-state network connectivity.

Dotterer Hailey L HL Hyde Luke W LW Shaw Daniel S DS Rodgers Emma L EL Forbes Erika E EE Beltz Adriene M AM

NeuroImage. Clinical 20200828

<h4>Background</h4>Psychopathic traits are hypothesized to be associated with dysfunction across three resting-state networks: the default mode (DMN), salience (SN), and central executive (CEN). Past work has not considered heterogeneity in the neural networks of individuals who display psychopathic traits, which is likely critical in understanding the etiology of psychopathy and could underlie different symptom presentations. Thus, this study maps person-specific resting state networks and link ...[more]

PMID: 32891038

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Project description:The human brain at rest exhibits intrinsic dynamics transitioning among the multiple metastable states of the inter-regional functional connectivity. Accordingly, the demand for exploring the state-specific functional connectivity increases for a deeper understanding of mental diseases. Functional connectivity, however, lacks information about the directed causal influences among the brain regions, called effective connectivity. This study presents the dynamic causal modeling (DCM) framework to explore the state-dependent effective connectivity using spectral DCM for the resting-state functional MRI (rsfMRI). We established the sequence of brain states using the hidden Markov model with the multivariate autoregressive coefficients of rsfMRI, summarizing the functional connectivity. We decomposed the state-dependent effective connectivity using a parametric empirical Bayes scheme that models the effective connectivity of consecutive windows with the time course of the discrete states as regressors. We showed the plausibility of the state-dependent effective connectivity analysis in a simulation setting. To test the clinical applicability, we applied the proposed method to characterize the state- and subtype-dependent effective connectivity of the default mode network in children with combined-type attention deficit hyperactivity disorder (ADHD-C) compared with age-matched, typically developed children (TDC). All 88 children were subtyped according to the occupation times (i.e., dwell times) of the three dominant functional connectivity states, independently of clinical diagnosis. The state-dependent effective connectivity differences between ADHD-C and TDC according to the subtypes and those between the subtypes of ADHD-C were expressed mainly in self-inhibition, magnifying the importance of excitation inhibition balance in the subtyping. These findings provide a clear motivation for decomposing the state-dependent dynamic effective connectivity and state-dependent analysis of the directed coupling in exploring mental diseases.

Project description:BACKGROUND:Drifts between wakefulness and sleep are common during resting state functional MRI (rsfMRI). Among healthy adults, within-scanner sleep can impact functional connectivity of default mode (DMN), task-positive (TPN), and thalamo-cortical networks. Because dysfunctional arousal states (i.e., sleepiness, sleep disturbance) are common in affective disorders, individuals with affective psychopathology may be more prone to unstable wakefulness during rsfMRI, hampering the estimation of clinically meaningful functional connectivity biomarkers. METHODS:A transdiagnostic sample of 150 young adults (68 psychologically distressed; 82 psychiatrically healthy) completed rsfMRI and reported whether they experienced within-scanner sleep. Symptom scales were reduced into depression/anxiety and mania proneness dimensions using principal component analysis. We evaluated associations between within-scanner sleep, clinical status, and functional connectivity of the DMN, TPN, and thalamus. RESULTS:Within-scanner sleep during rsfMRI was reported by 44% of participants (n?=?66) but was unrelated to psychiatric diagnoses or mood symptom severity (p-values > 0.05). Across all participants, self-reported within-scanner sleep was associated with connectivity signatures akin to objectively-assessed sleep, including lower within-DMN connectivity, lower DMN-TPN anti-correlation, and altered thalamo-cortical connectivity (p < 0.05, corrected). Among participants reporting sustained wakefulness (n?=?84), depression/anxiety severity positively associated with averaged DMN-TPN connectivity and mania proneness negatively associated with averaged thalamus-DMN connectivity (p-values < 0.05). Both relationships were attenuated and became non-significant when participants reporting within-scanner sleep were included (p-values > 0.05). LIMITATIONS:Subjective report of within-scanner sleep. CONCLUSIONS:Findings implicate within-scanner sleep as a source of variance in network connectivity; careful monitoring and correction for within-scanner sleep may enhance our ability to characterize network signatures underlying affective psychopathology.

Dataset Information

Connections that characterize callousness: Affective features of psychopathy are associated with personalized patterns of resting-state network connectivity.

Publications

Connections that characterize callousness: Affective features of psychopathy are associated with personalized patterns of resting-state network connectivity.

Similar Datasets

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