The Bidirectional Relationship Between Sleep and Inflammation Links Traumatic Brain Injury and Alzheimer's Disease.
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ABSTRACT:
SUBMITTER: Green TRF
PROVIDER: S-EPMC7479838 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Publications
The Bidirectional Relationship Between Sleep and Inflammation Links Traumatic Brain Injury and Alzheimer's Disease.
Green Tabitha R F TRF Ortiz J Bryce JB Wonnacott Sue S Williams Robert J RJ Rowe Rachel K RK
Frontiers in neuroscience 20200825
Traumatic brain injury (TBI) and Alzheimer's disease (AD) are diseases during which the fine-tuned autoregulation of the brain is lost. Despite the stark contrast in their causal mechanisms, both TBI and AD are conditions which elicit a neuroinflammatory response that is coupled with physical, cognitive, and affective symptoms. One commonly reported symptom in both TBI and AD patients is disturbed sleep. Sleep is regulated by circadian and homeostatic processes such that pathological inflammatio ...[more]
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