Ontology highlight
ABSTRACT:
SUBMITTER: Zhao LD
PROVIDER: S-EPMC7480142 | biostudies-literature | 2020 Nov
REPOSITORIES: biostudies-literature
Experimental and therapeutic medicine 20200903 5
Cellular senescence decreases cell proliferation over time and is characterized by typical markers, including larger cell volume, a flattened morphology, irreversible cell cycle arrest, augmentation of senescence-associated β-galactosidase (SA-β-gal) activity and senescence-associated secretory phenotype. A variety of factors are implicated in the process of cellular aging, which mediates an organisms' lifespan. Insulin-like growth factor-1 (IGF-1) serves an essential role in regulating cell gro ...[more]