Short-acting testosterone appears to have lesser effect on male reproductive potential compared to long-acting testosterone in mice.

ABSTRACT:

Objective

To compare the effect of exogenous short-acting and long-acting testosterone on male reproductive potential in mice.

Design

In vivo mouse model.

Setting

University-based basic science research laboratory.

Animals

A total of 30 wild-type C57BL/6 male and female mice were used for this experimentation. The male mice were used for control group and testosterone supplementation, while both male and female mice were used for the breeding portion of the study.

Interventions

Exogenous testosterone was administered either in short-acting formulation (Monday-Wednesday-Friday dosing schedule, testosterone propionate 0.2 mg/kg), or long-acting formulation (3-month dosing schedule - testosterone pellets 150 mg) to male mice.

Main outcome measures

SUBMITTER: Chu KY 

PROVIDER: S-EPMC7480784 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature