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Development and characterization of a photocurable alginate bioink for three-dimensional bioprinting.

ABSTRACT: Alginate is a biocompatible material suitable for biomedical applications, which can be processed under mild conditions on irradiation. This paper investigates the preparation and the rheological behavior of different pre-polymerized and polymerized alginate methacrylate systems for three-dimensional photopolymerization bioprinting. The effect of the functionalization time on the mechanical, morphological, swelling, and degradation characteristics of cross-linked alginate hydrogel is also discussed. Alginate was chemically-modified with methacrylate groups and different reaction times considered. Photocurable alginate systems were prepared by dissolving functionalized alginate with 0.5- 1.5% w/v photoinitiator solutions and cross-linked by ultraviolet light (8 mW/cm2 for 8 minutes).

SUBMITTER: Mishbak HH

PROVIDER: S-EPMC7481104 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Development and characterization of a photocurable alginate bioink for three-dimensional bioprinting.

Mishbak H H HH Cooper Glen G Bartolo P J PJ

International journal of bioprinting 20190701 2

Alginate is a biocompatible material suitable for biomedical applications, which can be processed under mild conditions on irradiation. This paper investigates the preparation and the rheological behavior of different pre-polymerized and polymerized alginate methacrylate systems for three-dimensional photopolymerization bioprinting. The effect of the functionalization time on the mechanical, morphological, swelling, and degradation characteristics of cross-linked alginate hydrogel is also discus ...[more]

PMID: 32954039

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