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Structures and Functions of the 3' Untranslated Regions of Positive-Sense Single-Stranded RNA Viruses Infecting Humans and Animals.

ABSTRACT: The 3' untranslated region (3' UTR) of positive-sense single-stranded RNA [ssRNA(+)] viruses is highly structured. Multiple elements in the region interact with other nucleotides and proteins of viral and cellular origin to regulate various aspects of the virus life cycle such as replication, translation, and the host-cell response. This review attempts to summarize the primary and higher order structures identified in the 3'UTR of ssRNA(+) viruses and their functional roles.

SUBMITTER: Liu Y

PROVIDER: S-EPMC7481400 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature

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Structures and Functions of the 3' Untranslated Regions of Positive-Sense Single-Stranded RNA Viruses Infecting Humans and Animals.

Liu Yuanzhi Y Zhang Yu Y Wang Mingshu M Cheng Anchun A Yang Qiao Q Wu Ying Y Jia Renyong R Liu Mafeng M Zhu Dekang D Chen Shun S Zhang Shaqiu S Zhao XinXin X Huang Juan J Mao Sai S Ou Xumin X Gao Qun Q Wang Yin Y Xu Zhiwen Z Chen Zhengli Z Zhu Ling L Luo Qihui Q Liu Yunya Y Yu Yanling Y Zhang Ling L Tian Bin B Pan Leichang L Chen Xiaoyue X

Frontiers in cellular and infection microbiology 20200827

The 3' untranslated region (3' UTR) of positive-sense single-stranded RNA [ssRNA(+)] viruses is highly structured. Multiple elements in the region interact with other nucleotides and proteins of viral and cellular origin to regulate various aspects of the virus life cycle such as replication, translation, and the host-cell response. This review attempts to summarize the primary and higher order structures identified in the 3'UTR of ssRNA(+) viruses and their functional roles. ...[more]

PMID: 32974223

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