Ontology highlight
ABSTRACT:
SUBMITTER: Zhang B
PROVIDER: S-EPMC7481651 | biostudies-literature | 2020 Aug
REPOSITORIES: biostudies-literature
Zhang Bei B Jia Kun K Tian Jing J Du Heng H
Biochemical and biophysical research communications 20200701 2
Mitochondria play an essential role in maintaining intraneuronal calcium homeostasis. Mitochondrial calcium uniporter (MCU) is a determined major brain mitochondrial calcium entry pathway. Activated MCU-mediated mitochondrial calcium overloading has been linked with brain mitochondrial pathology in disease conditions. Cyclophilin D (CypD)-mediated mitochondrial permeability transition (mPT) favors mitochondrial calcium efflux. The physiological function of CypD-mediated mPT has received increasi ...[more]