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Suggestions for improving the visualization of magnetic resonance spectroscopy voxels and spectra.

ABSTRACT: Magnetic resonance spectroscopy (MRS) has seen an increase in popularity as a method for studying the human brain. This approach is dependent on voxel localization and spectral quality, knowledge of which are essential for judging the validity and robustness of any analysis. As such, visualization plays a central role in appropriately communicating MRS studies. The quality of data visualization has been shown to be poor in a number of biomedical fields and so we sought to appraise this in MRS papers. To do this, we conducted a survey of the psychiatric single-voxel MRS literature. This revealed a generally low standard, with a significant proportion of papers not providing the voxel location and spectral quality information required to judge their validity or replicate the experiment. Based on this, we then present a series of suggestions for a minimal standard for MRS data visualization. The primary point of these is that both voxel location and MRS spectra be presented from all participants. Participant group membership should be indicated where more than one is included in the experiment (e.g. patients and controls). A set of suggested figure layouts that fulfil these requirements are presented with sample code provided to produce these (github.com/nwd2918/MRS-voxel-plot).

SUBMITTER: Truong V

PROVIDER: S-EPMC7481722 | biostudies-literature | 2020 Aug

REPOSITORIES: biostudies-literature

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Suggestions for improving the visualization of magnetic resonance spectroscopy voxels and spectra.

Truong Vuong V Duncan Niall W NW

Royal Society open science 20200805 8

Magnetic resonance spectroscopy (MRS) has seen an increase in popularity as a method for studying the human brain. This approach is dependent on voxel localization and spectral quality, knowledge of which are essential for judging the validity and robustness of any analysis. As such, visualization plays a central role in appropriately communicating MRS studies. The quality of data visualization has been shown to be poor in a number of biomedical fields and so we sought to appraise this in MRS pa ...[more]

PMID: 32968522

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Project description:Medulloblastoma (MB) is the most common malignant brain tumor occurring in childhood and rarely found in adult. Based on transcriptome profile MB are currently classified into four major molecular groups reflecting a considerable biological heterogeneity: WNT-activated, SHH-activated, group 3 and group 4. Recently, DNA methylation profiling allowed the identification of additional subgroups within the four major molecular groups associated with different clinic-pathological and molecular features. Isocitrate Dehydrogenase-1 (IDH1) mutations have been described in several tumours, including gliomas, while in MB are exceptionally reported and not routinely investigated. By mean of magnetic resonance spectroscopy (MRS) we unequivocally assessed the presence the oncometabolite D-2-Hydroxyglutarate (2HG), a marker of IDH1 and IDH2 mutation, in a case of adult MB. Immunophenotypical work-up and methylation profiling assigned the diagnosis of MB, subclass SHH-A, and molecular testing revealed the presence of the non-canonical somatic IDH1(p.R132C) mutation and an additional GNAS mutation, also exceptionally described in MB. To our knowledge this is the first reported case of MB harboring both mutations together. Of note, tumour exhibited a heterogeneous phenotype with a tumour component displaying glial differentiation, with robust GFAP expression, and a component with conventional MB features and selective presence of GNAS mutation, suggesting coexistence of two different major tumour clones. These findings draw attention to the need of a deeper genetic characterization of MB in order to get insights into their biology and improve stratification and clinical management of the patients. Moreover, reported data underling the importance of performing MRS for the identification of IDH mutations in non-glial tumours. The use of throughput molecular profiling analysis and advanced medical imaging technology will certainly increase the frequency with which rare tumour entities will be identified. Whether they have any particular therapeutic implications or prognostic relevance requires further investigations.

Dataset Information

Suggestions for improving the visualization of magnetic resonance spectroscopy voxels and spectra.

Publications

Suggestions for improving the visualization of magnetic resonance spectroscopy voxels and spectra.

Similar Datasets

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