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Subscapularis pyomyositis presenting as shoulder stiffness mistaken as frozen shoulder in young female: a case report.

ABSTRACT: Pyomyositis of the shoulder region in young healthy patients is rare but can lead to fatal overwhelming sepsis. Here we present the case of an otherwise healthy 32-year-old female patient with pain and stiffness in the right shoulder. Initial treatment with physical therapy and injection was ineffective. Magnetic resonance imaging of the right shoulder suggested subscapularis intramuscular sarcoma but excision of the muscle and biopsy revealed organized subscapularis pyomyositis. This case demonstrates the importance of investigating predisposing conditions in young patients with painful stiffness mimicking frozen shoulder that does not respond to nonoperative treatment.

SUBMITTER: Park IK

PROVIDER: S-EPMC7481751 | biostudies-literature | 2020 Nov

REPOSITORIES: biostudies-literature

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Subscapularis pyomyositis presenting as shoulder stiffness mistaken as frozen shoulder in young female: a case report.

Park In Keun IK Jang Suk-Hwan SH

Radiology case reports 20200906 11

Pyomyositis of the shoulder region in young healthy patients is rare but can lead to fatal overwhelming sepsis. Here we present the case of an otherwise healthy 32-year-old female patient with pain and stiffness in the right shoulder. Initial treatment with physical therapy and injection was ineffective. Magnetic resonance imaging of the right shoulder suggested subscapularis intramuscular sarcoma but excision of the muscle and biopsy revealed organized subscapularis pyomyositis. This case demon ...[more]

PMID: 32944117

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Project description:RationalePyomyositis is a microbial infection of the muscles and contributes to local abscess formation. Staphylococcus aureus frequently causes pyomyositis; however, transient bacteremia hinders positive blood cultures and needle aspiration does not yield pus, especially at the early disease stage. Therefore, identifying the pathogen is challenging, even if bacterial pyomyositis is suspected. Herein, we report a case of primary pyomyositis in an immunocompetent individual, with the identification of S aureus by repeated blood cultures.Patient concernsA 21-year-old healthy man presented with fever and pain from the left chest to the shoulder during motion. Physical examination revealed tenderness in the left chest wall that was focused on the subclavicular area. Ultrasonography showed soft tissue thickening around the intercostal muscles, and magnetic resonance imaging with short-tau inversion recovery showed hyperintensity at the same site. Oral nonsteroidal anti-inflammatory drugs for suspected virus-induced epidemic myalgia did not improve the patient's symptoms. Repeated blood cultures on days 0 and 8 were sterile. In contrast, inflammation of the soft tissue around the intercostal muscle was extended on ultrasonography.DiagnosesThe blood culture on day 15 was positive, revealing methicillin-susceptible S aureus JARB-OU2579 isolates, and the patient was treated with intravenous cefazolin.InterventionsComputed tomography-guided needle aspiration from the soft tissue around the intercostal muscle without abscess formation was performed on day 17, and the culture revealed the same clone of S aureus.OutcomesThe patient was diagnosed with S aureus-induced primary intercostal pyomyositis and was successfully treated with intravenous cefazolin for 2 weeks followed by oral cephalexin for 6 weeks.LessonsThe pyomyositis-causing pathogen can be identified by repeated blood cultures even when pyomyositis is non-purulent but suspected based on physical examination, ultrasonography, and magnetic resonance imaging findings.

Project description:IntroductionFrozen shoulder is a common, fibro-proliferative disease characterised by the insidious onset of pain and progressively restricted range of shoulder movement. Despite the prevalence of this disease, there is limited understanding of the molecular mechanisms underpinning the pathogenesis of this debilitating disease. Previous studies have identified increased myofibroblast differentiation and proliferation, immune cell influx and dysregulated cytokine production. We hypothesised that subpopulations within the fibroblast compartment may take on an activated phenotype, thus initiating the inflammatory processes observed in frozen shoulder. Therefore, we sought to evaluate the presence and possible pathogenic role of known stromal activation proteins in Frozen shoulder.MethodsShoulder capsule samples were collected from 10 patients with idiopathic frozen shoulder and 10 patients undergoing shoulder stabilisation surgery. Fibroblast activation marker expression (CD248, CD146, VCAM and PDPN, FAP) was quantified using immunohistochemistry. Control and diseased fibroblasts were cultured for in vitro studies from capsule biopsies from instability and frozen shoulder surgeries, respectively. The inflammatory profile and effects of IL-1β upon diseased and control fibroblasts was assessed using ELISA, immunohistochemistry and qPCR.ResultsImmunohistochemistry demonstrated increased expression of fibroblast activation markers CD248, CD146, VCAM and PDPN in the frozen shoulder group compared with control (p < 0.05). Fibroblasts cultured from diseased capsule produced elevated levels of inflammatory protein (IL-6, IL-8 & CCL-20) in comparison to control fibroblasts. Exposing control fibroblasts to an inflammatory stimuli, (IL-1ß) significantly increased stromal activation marker transcript and protein expression (CD248, PDPN and VCAM).ConclusionsThese results show that fibroblasts have an activated phenotype in frozen shoulder and this is associated with inflammatory cytokine dysregulation. Furthermore, it supports the hypothesis that activated fibroblasts may be involved in regulating the inflammatory and fibrotic processes involved in this disease.

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Subscapularis pyomyositis presenting as shoulder stiffness mistaken as frozen shoulder in young female: a case report.

Publications

Subscapularis pyomyositis presenting as shoulder stiffness mistaken as frozen shoulder in young female: a case report.

Similar Datasets

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