Ontology highlight
ABSTRACT:
SUBMITTER: Berger E
PROVIDER: S-EPMC7481887 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Berger Emmanuelle E Colosetti Pascal P Jalabert Audrey A Meugnier Emmanuelle E Wiklander Oscar P B OPB Jouhet Juliette J Errazurig-Cerda Elisabeth E Chanon Stéphanie S Gupta Dhanu D Rautureau Gilles J P GJP Geloen Alain A El-Andaloussi Samir S Panthu Baptiste B Rieusset Jennifer J Rome Sophie S
Molecular therapy. Methods & clinical development 20200814
We have determined whether orange juice-derived nanovesicles (ONVs) could be used for the treatment of obesity-associated intestinal complications. ONVs were characterized by lipidomic, metabolomic, electron microscopy. <i>In vitro</i>, intestinal barriers (IBs = Caco-2+HT-29-MTX) were treated with ONVs and co-cultured with adipocytes to monitor IB fat release. <i>In vivo</i>, obesity was induced with a high-fat, high-sucrose diet (HFHSD mice) for 12 weeks. Then, half of HFHSD mice were gavaged ...[more]