Ontology highlight
ABSTRACT:
SUBMITTER: Mondragon-Rodriguez S
PROVIDER: S-EPMC7481966 | biostudies-literature | 2020
REPOSITORIES: biostudies-literature
Mondragón-Rodríguez Siddhartha S Salgado-Burgos Humberto H Peña-Ortega Fernando F
Neural plasticity 20200901
For more than five decades, the field of Alzheimer's disease (AD) has focused on two main hypotheses positing amyloid-beta (A<i>β</i>) and Tau phosphorylation (pTau) as key pathogenic mediators. In line with these canonical hypotheses, several groups around the world have shown that the synaptotoxicity in AD depends mainly on the increase in pTau levels. Confronting this leading hypothesis, a few years ago, we reported that the increase in phosphorylation levels of dendritic Tau, at its microtub ...[more]