Ontology highlight
ABSTRACT:
SUBMITTER: Hughes AN
PROVIDER: S-EPMC7483351 | biostudies-literature | 2020 Sep
REPOSITORIES: biostudies-literature
Hughes Alexandria N AN Appel Bruce B
Nature neuroscience 20200706 9
During development, oligodendrocytes contact and wrap neuronal axons with myelin. Similarly to neurons and synapses, excess myelin sheaths are produced and selectively eliminated, but how elimination occurs is unknown. Microglia, the resident immune cells of the central nervous system, engulf surplus neurons and synapses. To determine whether microglia also prune myelin sheaths, we used zebrafish to visualize and manipulate interactions between microglia, oligodendrocytes, and neurons during dev ...[more]